Bacterial evolution: dynamic genomes and the power of transformation

Guttman DS

Curr. Biol. 2009 Sep;19(18):R857-9

PubMed PMID: 19788881

Abstract

Virulence and avirulence genes carried on large, unstable pathogenicity islands (PAI) strongly influence the course and fate of host-pathogen interactions. A recent study shows how one such PAI can be rapidly transferred between two closely related bacteria via transformation in vivo, and how this horizontal gene transfer affects the fitness of the recipient strain.